S Factor Sonia and Silver, The by Aquaslash (V0.5) – Play Online SEGA Genesis
S1 Physics in Sonic 2 – Play Online SEGA Genesis
S1Fixed Beta – Play Online SEGA Genesis
SD Valis (Japan) – Play Online SEGA Genesis
Sagaia (USA) – Play Online SEGA Genesis
Saint Sword (Japan) – Play Online SEGA Genesis
Saint Sword (USA) – Play Online SEGA Genesis
Sally Acorn in Sonic the Hedgehog – Play Online SEGA Genesis
Same! Same! Same! (Japan) – Play Online SEGA Genesis
Sampras Tennis 96 (Europe) (J-Cart) – Play Online SEGA Genesis
Samurai Shodown (USA) – Play Online SEGA Genesis
Samurai Spirits (Japan) – Play Online SEGA Genesis
Sangokushi II (Japan) – Play Online SEGA Genesis
Sangokushi III (Japan) – Play Online SEGA Genesis
Sangokushi Retsuden – Ransei no Eiyuutachi (Japan) – Play Online SEGA Genesis
Sanguozhi Liezhuan – Luanshi Qunying (China) – Play Online SEGA Genesis
Sanguozhi V (China) (Unl) – Play Online SEGA Genesis
SatAM Sonic in Sonic 3 & Knuckles – Play Online SEGA Genesis
Saturday Night Slammasters (Europe) – Play Online SEGA Genesis
Saturday Night Slammasters (USA) – Play Online SEGA Genesis
Scooby Doo Mystery (USA) – Play Online SEGA Genesis
Scourge in Sonic 3 – Play Online SEGA Genesis
SeaQuest DSV (Europe) – Play Online SEGA Genesis
SeaQuest DSV (USA) – Play Online SEGA Genesis
Second Samurai (Europe) – Play Online SEGA Genesis
Sega Sports 1 (Europe) – Play Online SEGA Genesis
Sega Top Five (Brazil) – Play Online SEGA Genesis
SegaSonic Bros – Play Online SEGA Genesis
Segapede (Prototype) – Play Online SEGA Genesis
Semi Ported Hyper Sonic in Sonic by Selbi (S1 Hack) – Play Online SEGA Genesis
Senjou no Ookami II ~ Mercs (World) – Play Online SEGA Genesis
Sensible Soccer (Europe) (En,Fr,De,It) – Play Online SEGA Genesis
Sensible Soccer – International Edition (Europe) (En,Fr,De,It) – Play Online SEGA Genesis
Sesame Street Counting Cafe (USA) – Play Online SEGA Genesis
Shadow & Rouge in sonic 2 – Play Online SEGA Genesis
Shadow Blasters (USA) – Play Online SEGA Genesis
Shadow Dancer – The Secret of Shinobi (World) – Play Online SEGA Genesis
Shadow in Sonic the Hedgehog 2 – Play Online SEGA Genesis
Shadow of the Beast (USA, Europe) – Play Online SEGA Genesis
Shadow of the Beast II (USA, Europe) – Play Online SEGA Genesis
Shadow of the Beast – Mashou no Okite (Japan) – Play Online SEGA Genesis
Shadow the Hedgehog in Sonic 1 – Play Online SEGA Genesis
Shadow the Hedgehog in Sonic the Hedgehog – Play Online SEGA Genesis
Shadowrun (Japan) – Play Online SEGA Genesis
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Shadowrun (USA) [Hack by Magus77 v2.2] (Conversion Mod) – Play Online SEGA Genesis
Shadowrun (USA) – Play Online SEGA Genesis
Sonic & Knuckles + Sonic the Hedgehog 3 (World) – Play Online SEGA Genesis
Sonic 2 Heroes – Play Online SEGA Genesis
Sonic 2 Rainbow Edition – Play Online SEGA Genesis
Sonic Classic Heroes – Play Online SEGA Genesis
Sonic Generations 2 – Play Online SEGA Genesis
Sonic The Hedgehog 2 – Play Online SEGA Genesis
Sonic The Hedgehog Fixed Version V1.3 – Play Online SEGA Genesis
Sonic The Hedgehog Nature Islands – Play Online SEGA Genesis
Sonic is alone. – Play Online SEGA Genesis
Sonic the Hedgehog 2 (World) (Rev A) – Play Online SEGA Genesis